Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies

Isis Wolf; Christian Gratzke; Philipp Wolf

doi:10.3389/fonc.2022.935715

Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies

Front Oncol. 2022 Jul 8:12:935715. doi: 10.3389/fonc.2022.935715. eCollection 2022.

Authors

Isis Wolf^{1

2}, Christian Gratzke^{1

2}, Philipp Wolf^{1

2}

Affiliations

¹ Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.
² Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Abstract

Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC.

Keywords: prostate cancer; prostate cancer stem cell antigens; prostate cancer stem cell hypothesis; prostate cancer stem cell therapy; prostate cancer stem cells.

Publication types

Review