Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Xin Ma; Yi Ru; Ying Luo; Le Kuai; Qi-Long Chen; Yun Bai; Ye-Qiang Liu; Jia Chen; Yue Luo; Jian-Kun Song; Mi Zhou; Bin Li

doi:10.3389/fcell.2022.942838

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Front Cell Dev Biol. 2022 Jul 7:10:942838. doi: 10.3389/fcell.2022.942838. eCollection 2022.

Authors

Xin Ma^{1

2}, Yi Ru^{1

3}, Ying Luo^{1

3}, Le Kuai^{1

3}, Qi-Long Chen², Yun Bai², Ye-Qiang Liu², Jia Chen², Yue Luo², Jian-Kun Song², Mi Zhou^{1

3}, Bin Li^{2

3}

Affiliations

¹ Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Shanghai Skin Disease Hospital of Tongji University, Shanghai, China.
³ Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.

Abstract

Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management.

Keywords: atopic dermatitis; epigenetics; post-translational modifications; skin disorders; therapeutic potential.

Publication types

Review