Roles of Non-Coding RNAs in Primary Biliary Cholangitis

Yaqin Zhang; Ziying Jiao; Mingwei Chen; Bing Shen; Zongwen Shuai

doi:10.3389/fmolb.2022.915993

Roles of Non-Coding RNAs in Primary Biliary Cholangitis

Front Mol Biosci. 2022 Jul 8:9:915993. doi: 10.3389/fmolb.2022.915993. eCollection 2022.

Authors

Yaqin Zhang¹, Ziying Jiao², Mingwei Chen³, Bing Shen², Zongwen Shuai¹

Affiliations

¹ Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
² Department of Physiology, School of Basic Medicine of Anhui Medical University, Hefei, China.
³ Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Abstract

Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly including microRNA, long non-coding RNA and circular RNA) plays a role in the pathological and biological processes of various diseases, especially autoimmune diseases. Many validated ncRNAs are expected to be biomarkers for the diagnosis or treatment of PBC. This review will elucidate the pathogenesis of PBC and help to identify potential ncRNA biomarkers for PBC.

Keywords: autoimmunity; biomarker; non-coding RNA; primary biliary cholangitis; ursodeoxycholic acid.

Publication types

Review