Role of prostate and bone stromal cells on prostate cancer progression

Sofia Karkampouna; Marianna Kruithof-de Julio; George N Thalmann

Role of prostate and bone stromal cells on prostate cancer progression

Am J Clin Exp Urol. 2022 Jun 15;10(3):180-187. eCollection 2022.

Authors

Sofia Karkampouna¹, Marianna Kruithof-de Julio^{1

2

3

4}, George N Thalmann^{1

4}

Affiliations

¹ Department for BioMedical Research DBMR, Urology Research Laboratory, University of Bern Bern, Switzerland.
² Translational Organoid Resource, Department for BioMedical Research, University of Bern Bern, Switzerland.
³ Bern Center for Precision Medicine, University of Bern and Inselspital Bern, Switzerland.
⁴ Department of Urology, Inselspital, Bern University Hospital Bern, Switzerland.

PMID: 35874291
PMCID: PMC9301059

Abstract

Prostate cancer is a highly heterogeneous disease, often manifesting in a metastatic form to the bone. Complex tumour cells and surrounding microenvironment interactions are important determinants of disease progression and therapy resistance. Here, we provide an overview of some of the early studies that recognized the pro-tumourigenic role of prostate stroma, particularly fibroblasts, bone stromal components, and its permissive tumour properties. This article is written in memory of Prof. Dr LWK Chung and his contributions. Prostate and bone metastasis stroma concepts emerging from his work are now more actively being pursued by the authors of this article and others in the field.

Keywords: LNCaP; Prostate cancer; bone metastasis; organoids; stroma; tumour microenvironment.

Publication types

Review