Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property

Sadaf Jamal Gilani; May Nasser Bin-Jumah; Fahad A Al-Abbasi; Syed Sarim Imam; Sultan Alshehri; Mohammed M Ghoneim; Muhammad Shahid Nadeem; Muhammad Afzal; Sami I Alzarea; Nadeem Sayyed; Imran Kazmi

doi:10.1021/acsomega.2c01406

Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property

ACS Omega. 2022 Jul 1;7(28):24231-24240. doi: 10.1021/acsomega.2c01406. eCollection 2022 Jul 19.

Authors

Affiliations

¹ Department of Basic Health Sciences, Preparatory Year, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
² Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
³ Environment and Biomaterial Unit, Health Sciences Research Center, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
⁴ Department of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah 21589, Saudi Arabia.
⁵ Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
⁶ Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia.
⁷ Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia.
⁸ Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh 247121, India.

Abstract

Objectives: Malvidin, a dietary anthocyanin can be a potent drug for the treatment of neuronal toxicity. The investigation was aimed to study the antioxidant role of malvidin against aluminum chloride (AlCl₃)-induced neurotoxicity in rats. Methods: To evaluate the neuroprotective role of malvidin, the rats were divided into four different groups: group I received saline, group II received AlCl₃, and groups III and IV were administered with 100 and 200 mg/kg malvidin after AlCl₃ for 60 days. During the evaluation period, all the groups were subjected to a behavioral test. On the 61st day of the study, rat brains were removed and used for a neurochemical assay. Results: From the present study, malvidin ameliorated the effects of AlCl₃ on behavioral parameters. Biochemical investigation revealed that oral treatment of malvidin shows neuroprotective effects through regulation of antioxidant levels and neuroinflammation in the AlCl₃-exposed rats. Conclusion: The results indicate that malvidin possesses antioxidant activity via acetylcholinesterase inhibition and regulation of oxidative stress in neuronal cells. Hence, malvidin could be a potential drug in correcting Alzheimer's disease.