We compared paired serum specimens from household contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases with detectable SARS-CoV-2 seroconversion with contacts who remained seronegative. No protection from SARS-CoV-2 infection was associated with human coronavirus antibodies; however, an increase in common betacoronavirus antibodies was associated with seroconversion to SARS-CoV-2 in mild to moderately ill cases.
Keywords: COVID-19; SARS-CoV-2; common coronaviruses; human coronaviruses; immunology.
Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.