IgM Positivity for Both EBV and CMV: A Clinical Conundrum

Tulip A Jhaveri; Courtney Harris; Paul E Sax

doi:10.1093/ofid/ofac316

IgM Positivity for Both EBV and CMV: A Clinical Conundrum

Open Forum Infect Dis. 2022 Jun 24;9(7):ofac316. doi: 10.1093/ofid/ofac316. eCollection 2022 Jul.

Authors

Tulip A Jhaveri¹, Courtney Harris², Paul E Sax²

Affiliations

¹ Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi, USA.
² Division of Infectious Diseases, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

A review of 28 patients who tested positive for both Epstein-Barr virus and cytomegalovirus immunoglobulin M at an academic medical center revealed that dual positivity is more common than previously reported. These cases require careful review of the history and sometimes supplemental testing. This report highlights features of patients with dual positivity and provides recommendations on interpretation of the results.

Keywords: EBV and CMV IgM; dual positivity.