Bibliometric Analysis of Cathepsin B Research From 2011 to 2021

Xiaoli Yang; Hua Yin; Deyu Zhang; Lisi Peng; Keliang Li; Fang Cui; Chuanchao Xia; Zhaoshen Li; Haojie Huang

doi:10.3389/fmed.2022.898455

Bibliometric Analysis of Cathepsin B Research From 2011 to 2021

Front Med (Lausanne). 2022 Jul 6:9:898455. doi: 10.3389/fmed.2022.898455. eCollection 2022.

Authors

Xiaoli Yang^{1

2}, Hua Yin^{1

2}, Deyu Zhang², Lisi Peng², Keliang Li³, Fang Cui², Chuanchao Xia², Zhaoshen Li², Haojie Huang²

Affiliations

¹ Department of Gastroenterology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China.
² Department of Gastroenterology, Changhai Hospital, Navy/Second Military Medical University, Shanghai, China.
³ Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Cathepsin B (CTSB) is a lysosomal protease implicated in the progression of various diseases. A large number of CTSB-related studies have been conducted to date. However, there is no comprehensive bibliometric analysis on this subject. In our study, we performed quantitative analysis of CTSB-related publications retrieved from the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection (reference period: 2011-2021). A total of 3,062 original articles and reviews were retrieved. The largest number of publications were from USA (n = 847, 27.66%). The research output of each country showed positive correlation with gross domestic product (GDP) (r = 0.9745, P < 0.0001). Active collaborations between countries/regions were also observed. Reinheckel T and Sloane BF were perhaps the most impactful researchers in the research landscape of CTSB. Plos ONE was the most prevalent (119/3,062, 3.89%) and cited journal (3,021 citations). Comprehensive analysis of the top citations, co-citations, and keywords was performed to acquire the theoretical basis and hotspots of CTSB-related research. The main topics included CTSB-related cancers and inflammatory diseases, CTSB-associated cell death pattern, and the applications of CTSB. These results provide comprehensive insights into the current status of global CTSB-related research especially in pancreas, which is worthy of continued follow-up by practitioners and clinicians in this field.

Keywords: Research Frontier; bibliometrics; cathepsin B; pancreatic diseases; visualization.