Synthesis of carbon dots-based covalent organic nanomaterial as stationary phase for open tubular capillary electrochromatography

Yuanyuan Fu; Zhentao Li; Changjun Hu; Qiaoyan Li; Zilin Chen

doi:10.1016/j.chroma.2022.463343

Synthesis of carbon dots-based covalent organic nanomaterial as stationary phase for open tubular capillary electrochromatography

J Chromatogr A. 2022 Aug 16:1678:463343. doi: 10.1016/j.chroma.2022.463343. Epub 2022 Jul 14.

Authors

Yuanyuan Fu¹, Zhentao Li¹, Changjun Hu¹, Qiaoyan Li¹, Zilin Chen²

Affiliations

¹ Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, School ofPharmaceutical Sciences, Wuhan University, Wuhan 430072, China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan, 430071, China.
² Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, School ofPharmaceutical Sciences, Wuhan University, Wuhan 430072, China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan, 430071, China. Electronic address: chenzl@whu.edu.cn.

PMID: 35872537
DOI: 10.1016/j.chroma.2022.463343

Abstract

The transformation of zero-dimensional carbon dots (CDs) to cross-linked nanomaterials is rare. In this work, a novel carbon dots-based covalent organic nanomaterial (CON CDs-TAPB) consisted of 1,3,5-tris(4-aminophenyl)-benzene (TAPB) and carbon dots (CDs) through facile Schiff-base reaction was synthesized and then employed as a stationary phase for open-tubular capillary electrochromatography (OT-CEC). The CON CDs-TAPB and the CDs-TAPB coated column were characterized through Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), UV-spectra experiments and X-ray photoelectron spectroscopy (XPS). Thanks to CON CDs-TAPB unique structure and abundant accessibility and interaction sites, the prepared column exhibited a satisfactory separation ability towards analytes including parabens, phenolic compounds. Among all analytes, the highest column efficiency was over 1.6 × 10⁵ plates·m^-1. In addition, affording methylbenzene loading capacity of 156.9 pmole, surpassing most of those materials-based OT-CEC reported thus far. Thus, the prepared carbon dots-based covalent organic nanomaterial (CON CDs-TAPB) gave a potential as a stationary phase in the separation science.

Keywords: Capillary electrochromatography; Carbon dots; Covalent organic nanomaterials; Open-tubular column; Stationary phase.

MeSH terms

Capillary Electrochromatography* / methods
Carbon
Nanostructures*
Phenols
Spectroscopy, Fourier Transform Infrared

Substances

Phenols
Carbon