A transcription factor helps Plasmodium falciparum gametocytogenesis take shape

Kyle Jarrod McLean; Jacquin C Niles

doi:10.1016/j.pt.2022.07.004

A transcription factor helps Plasmodium falciparum gametocytogenesis take shape

Trends Parasitol. 2022 Sep;38(9):722-723. doi: 10.1016/j.pt.2022.07.004. Epub 2022 Jul 21.

Authors

Kyle Jarrod McLean¹, Jacquin C Niles²

Affiliations

¹ Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: kjmclean@mit.edu.
² Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

PMID: 35871979
DOI: 10.1016/j.pt.2022.07.004

Abstract

The recent study by Campelo Morillo et al. has shown that one of the small number of non-ApiAP2 DNA-binding proteins in the Plasmodium falciparum genome acts as a transcription factor in the gametocytogenesis cascade and is responsible for the gametocyte's distinctive morphology.

Keywords: ApiAP2; HDP1; Plasmodium falciparum; gametocytes; gametocytogenesis; transcription factor.

Publication types

Comment

MeSH terms

Gene Expression Regulation
Plasmodium falciparum* / genetics
Transcription Factors* / genetics

Substances

Transcription Factors