Preleukemic has been used to describe children with a propensity to develop B cell acute lymphoblastic leukemia (B-ALL). However, leukemia-predisposing mutations can also be present in differentiated cells unable to transform. We postulate that preleukemia should only be used when such mutations arise in progenitors capable of evolving to B-ALL.
Keywords: childhood leukemia; genetic predisposition; mouse models; preclinical; prevention.
Copyright © 2022 Elsevier Inc. All rights reserved.