Chronic kidney diseasehas been associated with changes in the function and composition of the gut microbiota. The ecosystem of the human gut consists of trillions of microorganisms forming an authentic metabolically active organ that is fueled by nutrients to produce bioactive compounds. These microbiota-derived metabolites may be protective for kidney function (e.g., short-chain fatty acids from fermentation of dietary fibers) or deleterious (e.g., gut-derived uremic toxins such as trimethylamine N-oxide, p-cresyl sulfate, and indoxyl sulfate from fermentation of amino acids). Although diet is the cornerstone of the management of the patient with chronic kidney disease, it remains a relatively underused component of the clinician's armamentarium. In this review, we describe the latest advances in understanding the diet-microbiota crosstalk in the uremic context and how this communication might contribute to chronic kidney disease progression and complications. We then discuss how this knowledge could be harnessed for personalized nutrition strategies to prevent patients with chronic kidney disease progressing tokidney failureand its detrimental consequences.
Keywords: chronic kidney disease; diet; gut microbiota; protein intake; uremic toxins.
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