The progress on porous organic materials for chiral separation

Abstract

Chiral compounds have similar structures and properties, but their pharmacological action is very different or even opposite. Therefore, the separation of chiral compounds has great significance in pharmaceutical and agriculture. Porous organic materials are novel crystalline porous materials, which possess high surface area, controllable pore size, and favorable functionalization. Therefore, porous organic materials are considered to be an ideal material for chiral separation. In this review, we summarized the progress of chiral porous organic materials for chiral separation in recent years. Furthermore, the applications of chiral porous organic materials as chiral separation medias (chromatography stationary phases and membrane materials) in enantioseparation were highlighted. Finally, the remaining challenges and future directions for porous organic materials in chiral separation were also briefly outlined further to promote the development of porous organic materials in chiral separation.

Keywords: Chiral separation; Chiral stationary phases; Membrane; Porous organic materials.