Denileukin diftitox-induced systemic capillary leak syndrome with acute kidney injury

Abstract

Systemic capillary leak syndrome is a rare and life-threatening disorder, characterized by recurrent episodes of unexplained hypotension, hemoconcentration, and hypoalbuminemia. This condition is caused by leakage of plasma and proteins into the extravascular space and can be classified as either idiopathic or secondary. Secondary systemic capillary leak syndrome can result from cancer, infections, medications, or surgery. Systemic capillary leak syndrome frequently develops as a side effect of denileukin diftitox treatment of refractory cutaneous T-cell lymphoma. However, the pathophysiology of this disease is not well understood. Herein, we report a case of denileukin diftitox-induced systemic capillary leak syndrome.

Keywords: 99mTc-HSA scintigraphy; Acute kidney injury; Cutaneous T-cell lymphoma; Denileukin diftitox; Interleukin-2 receptors; Systemic capillary leak syndrome.