Comparison of cellulose derivatives for Ca2+ and Zn2+ adsorption: Binding behavior and in vivo bioavailability

Xiangxiang He; Cuixia Sun; Hoda Khalesi; Yuyan Yang; Jingwen Zhao; Yin Zhang; Yangbing Wen; Yapeng Fang

doi:10.1016/j.carbpol.2022.119837

Comparison of cellulose derivatives for Ca²⁺ and Zn²⁺ adsorption: Binding behavior and in vivo bioavailability

Carbohydr Polym. 2022 Oct 15:294:119837. doi: 10.1016/j.carbpol.2022.119837. Epub 2022 Jul 7.

Authors

Xiangxiang He¹, Cuixia Sun¹, Hoda Khalesi¹, Yuyan Yang¹, Jingwen Zhao¹, Yin Zhang², Yangbing Wen³, Yapeng Fang⁴

Affiliations

¹ Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
² Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu 610106, China.
³ Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China.
⁴ Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: ypfang@sjtu.edu.cn.

PMID: 35868780
DOI: 10.1016/j.carbpol.2022.119837

Abstract

Cellulose with distinct colloidal states exhibited different adsorption capability for ions and whether the intake of cellulose would bring positive or negative influence on the mineral bioavailability is inconclusive. This work investigated the binding behavior of carboxymethyl cellulose (CMC), TEMPO-oxidized nanofibrillated/nanocrystalline cellulose (TOCNF/TOCNC), and microcrystalline cellulose (MCC) with Ca²⁺and Zn²⁺ and compared their effects on mineral bioavailability in vitro and in vivo. The results suggested that CMC displayed a higher adsorption capability (36.6 mg g^-1 for Ca²⁺ and 66.2 mg g^-1 for Zn²⁺) than the other types of cellulose because of the strong interaction between carboxyl groups of cellulose and the ions. Although the cellulose derivatives had adverse effects on ion adsorption in vitro, the fermentability endowed by TOCNF/TOCNC counterbalanced the negative impacts in vivo. The findings suggested that the colloidal states of cellulose affected the bioavailability of minerals and could provide useful guidance for applications of specific cellulose.

Keywords: Adsorption; Bioavailability; Ca(2+); Cellulose derivatives; Colloidal states; Zn(2+).

MeSH terms

Adsorption
Biological Availability
Carboxymethylcellulose Sodium*
Cellulose* / chemistry
Ions
Minerals
Zinc

Substances

Ions
Minerals
Cellulose
Zinc
Carboxymethylcellulose Sodium