HOXA13 promotes liver regeneration through regulation of BMP-7

Beiyong Cui; Liu Yang; Yingying Zhao; Xiya Lu; Meiyi Song; Chang Liu; Changqing Yang

doi:10.1016/j.bbrc.2022.07.018

HOXA13 promotes liver regeneration through regulation of BMP-7

Biochem Biophys Res Commun. 2022 Oct 1:623:23-31. doi: 10.1016/j.bbrc.2022.07.018. Epub 2022 Jul 14.

Authors

Beiyong Cui¹, Liu Yang¹, Yingying Zhao², Xiya Lu³, Meiyi Song⁴, Chang Liu⁵, Changqing Yang⁶

Affiliations

¹ Division of Gastroenterology and Hepatology, Digestive Disease Institute, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
² Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China.
³ Department of Endoscopy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, PR China.
⁴ Division of Gastroenterology and Hepatology, Digestive Disease Institute, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. Electronic address: 1610688@tongji.edu.cn.
⁵ Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, 200444, China. Electronic address: liuchang05@shu.edu.cn.
⁶ Division of Gastroenterology and Hepatology, Digestive Disease Institute, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. Electronic address: cqyang@tongji.edu.cn.

PMID: 35868069
DOI: 10.1016/j.bbrc.2022.07.018

Abstract

In-depth knowledge of liver regeneration could facilitate the development of therapies for liver injury and liver failure. As a member of the homeobox superfamily, HOXA13 plays an important role in regulating tumorigenesis and development. However, the exact role of HOXA13 in liver regeneration remains unclear. In this study, we confirmed that HOXA13 promotes hepatocyte proliferation both in vivo and in vitro. HOXA13 was upregulated during liver regeneration, and its overexpression further accelerated hepatocyte proliferation and liver function recovery during liver regeneration. Furthermore, we found that HOXA13 promoted hepatocyte proliferation and liver regeneration by upregulating bone morphogenetic protein-7 (BMP-7) mRNA. These findings provide a new potential target for the treatment of liver failure.

Keywords: Bone morphogenetic protein-7; HOXA13; Liver regeneration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bone Morphogenetic Protein 7* / genetics
Cell Proliferation
Homeodomain Proteins / genetics
Humans
Liver Failure*
Liver Regeneration / genetics

Substances

Bone Morphogenetic Protein 7
Homeodomain Proteins