The growing number of nanomaterials-based-products ranging from agriculture to cosmetics to medical, and so on, increases the amount of exposure, compelling researchers to include safety and health protocols in each developed nano-product to ensure consumer safety. As a result, emphasizing the importance of novel nanomaterials' toxicological and safety profiles, as well as their product quality enhancement, is critical. As a result, research efforts must be directed toward developing new nanomaterials in a safer-by-design manner. Chitosan functionalization is an excellent option for this because it is already known for its nontoxicity, biodegradability, and biocompatibility. In this review, we hope to uncover the toxicological consequences of nanomaterials and the potential role of chitosan functionalization in mitigating them. This is an effort to create an environmentally friendly and safe nano-product, ensuring tomorrow's sustainability.
Keywords: Chitosan functionalization; biocompatibility; carbon-based nanomaterial; metals-based nanomaterial; nanotoxicology; safe nanomaterials.