Successful implantation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film with good patency on follow-up angiography: A case report

Medicine (Baltimore). 2022 Jul 22;101(29):e29666. doi: 10.1097/MD.0000000000029666.

Abstract

Rationale: Despite technological advances in interventional cardiology during the last decades, many concerns remain regarding the narrowing and occlusion of the in-stent area. Particularly, polymer materials pose several problems, including chronic arterial inflammation, impaired arterial healing, and stent thrombosis. To avoid these complications, we invented the TIGEREVOLUTION stent with a cobalt-chromium alloy-based stent platform deposited with N-TiO2 film, which has demonstrated good biocompatibility. As this stent is not coated with polymer, it is expected to have decreased risk of stent thrombosis.

Patient concerns: A 62-year-old Korean man visited our department because of angina. We commenced coronary angiography (CAG).

Diagnosis: CAG revealed critical stenosis in the mid-portion of the right coronary artery, with a minimum lumen area of 1.08mm2 on optical coherence tomography (OCT).

Intervention: Percutaneous coronary intervention was performed with implantation of a novel 3.5 × 26-mm polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film (TIGEREVOLUTION® stent). Post-percutaneous coronary intervention OCT showed good stent expansion and apposition, and the patient was discharged successfully and uneventfully.

Outcomes: Eight months later, follow-up coronary angiography demonstrated good stent patency with no definitive evidence of in-stent restenosis, with thin stent strut coverage demonstrated on OCT.

Lessons: We report the first case of TIGEREVOLUTION stent implantation with follow-up OCT at 8 months.

Publication types

  • Case Reports

MeSH terms

  • Coronary Angiography
  • Coronary Vessels
  • Drug-Eluting Stents*
  • Everolimus
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Nitrogen
  • Nitrogen Dioxide
  • Percutaneous Coronary Intervention*
  • Polymers
  • Titanium
  • Tomography, Optical Coherence
  • Treatment Outcome

Substances

  • Polymers
  • titanium dioxide
  • Everolimus
  • Titanium
  • Nitrogen
  • Nitrogen Dioxide