Cytotoxic abietane diterpenoids from Salvia leriifolia Benth

Elham Sarhadi; Samad Nejad Ebrahimi; Abbas Hadjiakhoondi; Mahdi Abbas-Mohammadi; Azadeh Manayi; Valentina Parisi; Emanuela Pessolano; Antonello Petrella; Nunziatina De Tommasi

doi:10.1016/j.phytochem.2022.113310

Cytotoxic abietane diterpenoids from Salvia leriifolia Benth

Phytochemistry. 2022 Oct:202:113310. doi: 10.1016/j.phytochem.2022.113310. Epub 2022 Jul 19.

Authors

Elham Sarhadi¹, Samad Nejad Ebrahimi², Abbas Hadjiakhoondi³, Mahdi Abbas-Mohammadi⁴, Azadeh Manayi¹, Valentina Parisi⁵, Emanuela Pessolano⁵, Antonello Petrella⁵, Nunziatina De Tommasi⁶

Affiliations

¹ Medicinal Plants Research Centr, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
² Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran. Electronic address: s_ebrahimi@sbu.ac.ir.
³ Medicinal Plants Research Centr, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.
⁵ Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II N° 132, 84084, Fisciano, SA, Italy.
⁶ Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II N° 132, 84084, Fisciano, SA, Italy. Electronic address: detommasi@unisa.it.

PMID: 35863476
DOI: 10.1016/j.phytochem.2022.113310

Abstract

The Phytochemical profiling of the root extract of Salvia leriifolia, an endemic plant of Iran, was investigated and 16 abietane diterpenes were isolated, and three were original compounds. 1D and 2D NMR and HRMS performed structural elucidation. The absolute configuration of the previously unreported compounds was determined by circular dichroism (ECD). The cytotoxicity of the isolated compounds was investigated against AGS, MIA PaCa-2, HeLa, and MCF-7 cell lines by the MTT assay. The known diterpene pisiferal possesses high cytotoxicity against all investigated cell lines at a concentration between 9.3 ± 0.6 and 14.38 ± 1.4 μM.

Keywords: AGS cell; Diterpenoids; Lamiaceae; NMR; Phytochemical; Salvia leriifolia.

MeSH terms

Abietanes / chemistry
Abietanes / pharmacology
Antineoplastic Agents*
Antineoplastic Agents, Phytogenic* / chemistry
Antineoplastic Agents, Phytogenic* / pharmacology
Cell Line, Tumor
Diterpenes* / chemistry
Humans
Molecular Structure
Salvia* / chemistry

Substances

Abietanes
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Diterpenes