The need for speed: Migratory cells in tight spaces boost their molecular clock

Dhananjay Bhaskar; Alex M Hruska; Ian Y Wong

doi:10.1016/j.cels.2022.06.002

The need for speed: Migratory cells in tight spaces boost their molecular clock

Cell Syst. 2022 Jul 20;13(7):509-511. doi: 10.1016/j.cels.2022.06.002.

Authors

Dhananjay Bhaskar¹, Alex M Hruska¹, Ian Y Wong²

Affiliations

¹ School of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA.
² School of Engineering, Center for Biomedical Engineering, and Legoretta Cancer Center, Brown University, Providence, RI 02912, USA. Electronic address: ian_wong@brown.edu.

Abstract

Cells migrating in spatial confinement exhibit higher intracellular calcium levels, which increases the oscillation frequency of a "molecular clock" that synchronizes guanine nucleotide exchange factor GEF-H1 and microtubule polymerization for more frequent bursts of speed.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Microtubules*
Rho Guanine Nucleotide Exchange Factors

Substances

Rho Guanine Nucleotide Exchange Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding