The snow leopard (Panthera uncia) plays a vital role in maintaining the integrity of the high mountain ecosystem by regulating prey populations and maintaining plant community structure. Therefore, it is necessary to understand the role of the snow leopard and its interaction with prey species. Further, elucidating landscape use and co-occurrence of snow leopard and its prey species can be used to assess the differential use of habitat, allowing them to coexist. We used camera trapping and sign survey to study the interactions of snow leopard and its prey species (Siberian Ibex- Capra sibrica and Blue sheep-Pseudois nayaur) in the Spiti valley Himachal Pradesh. Using the occupancy modelling, we examined whether these prey and predator species occur together more or less frequently than would be expected by chance. To understand this, we have used ten covariates considering the ecology of the studied species. Our results suggest habitat covariates, such as LULC16 (barren area), LULC10 (grassland), ASP (aspect), SLP (slope) and DW (distance to water), are important drivers of habitat use for the snow leopard as well as its prey species. Furthermore, we found that the snow leopard detection probability was high if the site was used by its prey species, i.e., ibex and blue sheep. Whereas, in the case of the prey species, the probability of detection was low when the predator (snow leopard) was present and detected. Besides this, our results suggested that both species were less likely to detect together than expected if they were independent (Snow leopard-Ibex, Delta = 0.29, and snow leopard-blue sheep, Delta = 0.28, both the values are <1, i.e., avoidance). Moreover, despite the predation pressure, the differential anti-predation habitat selection and restriction of temporal activities by the prey species when snow leopard is present allows them to co-exist. Therefore, considering the strong link between the habitat use by the snow leopard and its prey species, it is imperative to generate quantitative long-term data on predator-prey densities and the population dynamics of its prey species in the landscape.