The Role of Blood-Brain Barrier Dysfunction in Mild Cognitive Impairment: a Scientometric and Visualization Analysis from 2000 to 2021

Ming Cai; Si Chen; Yihong Du; Siqi Li; Peihai Dong; Liyan Wang; Ruoyu Yang; Jingyun Hu; Lei Zhu

doi:10.1007/s12031-022-02052-4

The Role of Blood-Brain Barrier Dysfunction in Mild Cognitive Impairment: a Scientometric and Visualization Analysis from 2000 to 2021

J Mol Neurosci. 2022 Sep;72(9):1977-1989. doi: 10.1007/s12031-022-02052-4. Epub 2022 Jul 21.

Authors

Ming Cai^#^{1

2}, Si Chen^#³, Yihong Du^#⁴, Siqi Li³, Peihai Dong³, Liyan Wang⁵, Ruoyu Yang⁵, Jingyun Hu⁶, Lei Zhu⁷

Affiliations

¹ Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Shanghai, 201318, China.
² Bio-X Institutes, Shanghai Jiaotong University, Shanghai, 200030, China.
³ College of Sport Sciences, Qufu Normal University, Qufu, 273165, Shandong Province, China.
⁴ College of Physical and Health, East China Jiaotong University, Nanchang, China.
⁵ College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
⁶ Central Lab, Shanghai Pudong New Area People's Hospital, 490 Chuanhuan South Road, Shanghai, 201299, China. jingyunhu121@126.com.
⁷ College of Sport Sciences, Qufu Normal University, Qufu, 273165, Shandong Province, China. zhulei316@126.com.

^# Contributed equally.

PMID: 35861948
DOI: 10.1007/s12031-022-02052-4

Abstract

Mild cognitive impairment (MCI) is a pathological stage between normal cognitive aging and dementia. The blood-brain barrier (BBB) breakdown is emerging as an early biomarker of MCI. This study aimed to visually analyze the literatures related to MCI caused by BBB dysfunction in recent 20 years, systematically identify collaboration networks, track research trends, highlight current hot spots, and predict future frontiers in this field. The related literatures published from 2000 to 2021 were obtained from the Web of Science with the search term "mild cognitive impairment and (blood-brain barrier or neurovascular unit or neurovascular coupling)". VOSviewer software was used to present knowledge map, CiteSpace software was used to extract literature information and make tables, including the top most influential countries, authors, institutions, periodicals, keywords, and references. A total of 333 literatures were used for visual analysis. After 2013, the literatures in the field of BBB dysfunction-induced MCI showed an increased trend in terms of year of publication and quantity of material, with more than 40 publications published each year. USA, England, China, and Sweden cooperated closely. In terms of institutions, Harvard Med Sch ranked first in the number of papers published, followed by Mstricht Univ and Univ Washington. In terms of journals, three of the top five co-cited journals belonged to USA, the other two journals were Neurobiol Aging and J Alzheimers DIS, which were from England and Netherlands respectively. A total of 1752 authors were identified, with Abhay P Sagare the most published and Zlokovic BV the most cited. Keyword emergence detection analysis showed that inflammation, oxidative stress, and memory were new research hot spot in this field. Overall, the research on BBB dysfunction-induced MCI is booming. In the future, cooperation and communication between different countries and institutions should be strengthened.

Keywords: Bibliometric analysis; Blood–brain barrier; CiteSpace; Mild cognitive impairment; VOSviewer; Web of Science.

MeSH terms

Blood-Brain Barrier*
China
Cognitive Dysfunction*
Humans

Abstract

MeSH terms

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