Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics

Circulation. 2022 Jul 19;146(3):265-267. doi: 10.1161/CIRCULATIONAHA.122.059162. Epub 2022 Jul 18.

Shoa L Clarke^{1

2}, Rose D L Huang^{1

3}, Austin T Hilliard^{1

2}, Catherine Tcheandjieu^{1

2}, Julie Lynch⁴, Scott M Damrauer^{5

6}, Kyong-Mi Chang^{5

7}, Philip S Tsao^{1

2

8}, Themistocles L Assimes^{1

2

8}

¹ VA Palo Alto Health Care System, CA (S.L.C., R.D.L.H., A.T.H., C.T., P.S.T., T.L.A.).
² Department of Medicine, Division of Cardiovascular Medicine (S.L.C., A.T.H., C.T., P.S.T., T.L.A.), Stanford University School of Medicine, CA.
³ Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System (R.D.L.H.).
⁴ VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, UT (J.L.).
⁵ Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.M.D., K.-M.C.).
⁶ Departments of Surgery (S.M.D.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
⁷ Medicine (K.-M.C.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
⁸ Cardiovascular Institute (P.S.T., T.L.A.), Stanford University School of Medicine, CA.

No abstract available

Keywords: Hispanic or Latino; healthcare disparities; human genetics; precision medicine.

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