Neutrophils: New Critical Regulators of Glioma

Guanyu Wang; Jinpeng Wang; Chaoshi Niu; Yan Zhao; Pengfei Wu

doi:10.3389/fimmu.2022.927233

Neutrophils: New Critical Regulators of Glioma

Front Immunol. 2022 Jul 4:13:927233. doi: 10.3389/fimmu.2022.927233. eCollection 2022.

Authors

Guanyu Wang¹, Jinpeng Wang², Chaoshi Niu^{3

4

5

6}, Yan Zhao¹, Pengfei Wu^{3

4

5

6

7}

Affiliations

¹ Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
² Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
³ Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
⁴ Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, China.
⁵ Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, China.
⁶ Anhui Provincial Clinical Research Center for Neurosurgical Disease, Hefei, China.
⁷ Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, China.

Abstract

In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitumour effect. In this review, we focus on the functional roles of neutrophils in the circulation and tumour sites in patients with glioma. The mechanisms of neutrophil recruitment, immunosuppression and the differentiation of neutrophils are discussed. Finally, the potential of neutrophils as clinical biomarkers and therapeutic targets is highlighted. This review can help us gain a deeper and systematic understanding of the role of neutrophils, and provide new insights for treatment in gliomas.

Keywords: glioma; immunosuppression; neutrophils; treatment; tumour microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Glioma* / pathology
Glioma* / therapy
Humans
Immunosuppression Therapy
Neutrophil Infiltration
Neutrophils*
Tumor Microenvironment