Successful treatment of a child's pityriasis rubra pilaris (PRP) with ustekinumab and acitretin

Pediatr Dermatol. 2022 Jul;39(4):659-661. doi: 10.1111/pde.14994. Epub 2022 Jul 20.

Abstract

Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease that occurs with phenotypic variability in adults of all ages as well as in children. Data on the treatment of PRP is limited. Here, we report a 5-year-old girl with widespread skin involvement and prominent palmoplantar hyperkeratosis who was initially treated for psoriasis. After reevaluation, a diagnosis of PRP was made, and the patient had an excellent therapeutic response to ustekinumab and acitretin.

Keywords: children; pityriasis rubra pilaris; retinoids; successful treatment; ustekinumab.

Publication types

  • Case Reports

MeSH terms

  • Acitretin / therapeutic use
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Pityriasis Rubra Pilaris* / diagnosis
  • Pityriasis Rubra Pilaris* / drug therapy
  • Psoriasis* / drug therapy
  • Ustekinumab / therapeutic use

Substances

  • Ustekinumab
  • Acitretin