Low-grade albuminuria and its relationship with cardiovascular disease risk in hypertensive and diabetic patients in primary health care

Ramon Augusto Ferreira de Souza; Eunice Ferreira da Silva; Deíse Moura de Oliveira; Renata Maria Colodette; Rosângela Minardi Mitre Cotta; Luciana Saraiva da Silva; Tiago Ricardo Moreira

doi:10.1186/s12882-022-02884-7

Low-grade albuminuria and its relationship with cardiovascular disease risk in hypertensive and diabetic patients in primary health care

BMC Nephrol. 2022 Jul 20;23(1):257. doi: 10.1186/s12882-022-02884-7.

Authors

Ramon Augusto Ferreira de Souza¹, Eunice Ferreira da Silva¹, Deíse Moura de Oliveira¹, Renata Maria Colodette², Rosângela Minardi Mitre Cotta³, Luciana Saraiva da Silva⁴, Tiago Ricardo Moreira⁵

Affiliations

¹ Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
² Escola Nacional de Saúde Pública. Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
³ Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
⁴ Faculdade de Medicina. Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
⁵ Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa, Viçosa, MG, Brazil. tiago.ricardo@ufv.br.

Abstract

Objective: To evaluate the presence of LGA and the relationship with the 10-year risk of a cardiovascular event in hypertensive and diabetic patients in Primary Health Care.

Study design: The study design used is cross-sectional.

Methods: This study was based on the application of questionnaires, anthropometric measurements, and laboratory tests carried out from August 2017 to April 2018. Logistic regression was used to evaluate the odds ratio of the explanatory variables in relation to the highest tercile of LGA. The Framingham risk score was used to assess the 10-year risk of cardiovascular event. The comparison of this score with the LGA terciles was analyzed using ANOVA.

Results: An increase in the 10-year risk of cardiovascular event score was observed with an increasing LGA tercile, and this pattern prevailed after adjusting for confounding variables.

Conclusion: An association between LGA and the 10-year risk of cardiovascular event was observed in a representative sample of hypertensive and diabetic patients.

Keywords: Albuminuria; Cardiovascular diseases; Diabetes Mellitus; Hypertension; Risk factors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Albuminuria / epidemiology
Cardiovascular Diseases* / epidemiology
Cross-Sectional Studies
Diabetes Mellitus* / epidemiology
Humans
Hypertension* / epidemiology
Primary Health Care