Brucellosis is a neglected zoonosis and a public health problem in developing countries that also causes great economic losses in livestock. In Mexico it is endemic and Chiapas, a state in the south of the country, stands out for the presence of the disease in humans. Through the review of the state of the art it was found that factors such as the high production of cattle, the limited institutional strategies to control the disease in livestock, the lack of sanitary regulation of the genus Brucella in dairy and meat products and the location of the state of Chiapas on the border with Central America could be determining factors for the prevalence of human brucellosis in this region of Mexico.