Latest developments in the pathobiology of Ewing sarcoma

Irina Karlina; Brett A Schroeder; Kirill Kirgizov; Olga Romantsova; Andrey L Istranov; Andrey Nedorubov; Peter Timashev; Ilya Ulasov

doi:10.1016/j.jbo.2022.100440

Latest developments in the pathobiology of Ewing sarcoma

J Bone Oncol. 2022 Jul 1:35:100440. doi: 10.1016/j.jbo.2022.100440. eCollection 2022 Aug.

Authors

Irina Karlina¹, Brett A Schroeder², Kirill Kirgizov³, Olga Romantsova³, Andrey L Istranov⁴, Andrey Nedorubov⁵, Peter Timashev⁶, Ilya Ulasov¹

Affiliations

¹ Group of Experimental Biotherapy and Diagnostics, Institute for Regenerative Medicine, World-Class Research Centre "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.
² National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.
³ Research Institute of Pediatric Oncology and Hematology at N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia Moscow, 115478, Russia.
⁴ Department of Oncology, radiation therapy and plastic surgery, I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia.
⁵ Center for Preclinical Research, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
⁶ World-Class Research Centre "Digital Biodesign and Personalized Healthcare", Sechenov First Moscow State Medical University, Moscow 119991, Russia.

Abstract

Ewing's sarcoma (ES) is an aggressive malignant tumor commonly affecting adolescents. The standard of care includes surgical treatment and systemic therapies, although ES patients often develop drug resistance, leading to disease progression. Tumorigenesis in Ewing's sarcoma has unique characteristics that allow for the development of targeted therapeutics. New data on the role of oncogenic drivers in ES tumorigenesis, particularly in relation to treatment-induced stress, offers new therapeutic opportunities. This review summarizes the latest information on the clinically relevant oncogenes found in Ewing's sarcoma, their biological roles, and candidate targets for improving ES patient outcomes.

Keywords: Ewing’s sarcoma; Oncogenes; Pathogenesis; Pediatric oncology; Targeted therapy.

Publication types

Review