Juvenile psammomatoid ossifying fibroma of the parietal bone and review of calvarial presentations: illustrative case

Robert T Chung; Julio D Montejo; Darcy A Kerr; Jennifer Hong

doi:10.3171/CASE21361

Juvenile psammomatoid ossifying fibroma of the parietal bone and review of calvarial presentations: illustrative case

J Neurosurg Case Lessons. 2021 Sep 6;2(10):CASE21361. doi: 10.3171/CASE21361.

Authors

Robert T Chung¹, Julio D Montejo², Darcy A Kerr², Jennifer Hong³

Affiliations

¹ Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire; and.
² Departments of Neurosurgery, and.
³ Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Abstract

Background: Juvenile psammomatoid ossifying fibroma (JPOF) is an uncommon benign fibro-osseous lesion that only rarely presents in the calvaria.

Observations: The authors reported a case of JPOF in the left parietal bone of a 20-year-old patient and reviewed the 27 other cases of JPOF occurring in the calvaria as reported in the literature.

Lessons: JPOF rarely presents in the calvaria, and because diagnosis is a histopathologic one, clinicians should consider this entity when presented with a lytic, expansile mass on imaging. Little is known about the molecular mechanisms driving development of JPOF. MDM2 amplification may play a role, although this was not seen in the case presented herein.

Keywords: COF = cemento-ossifying fibroma; CT = computed tomography; EMA = epithelial membrane antigen; FISH = fluorescence in situ hybridization; JPOF; JPOF = juvenile psammomatoid ossifying fibroma; MRI = magnetic resonance imaging; PR = progesterone receptor; juvenile active ossifying fibroma; juvenile psammomatoid ossifying fibroma; ossifying fibroma.

Publication types

Case Reports