The clarity of taste sensation interaction is a key basis for promoting the food sensory science research and its application to the beverage and food additive industries. This study explored the synergy and antagonism effect of sucrose-citric acid mixture and established an optimized method to determine the human sweetness and sourness interactive response. Sucrose-citric acid mixtures were evaluated by the "close type" question. According to the sensory difference strength curves and Weber-Fechner law, citric acid increased the sucrose's absolute threshold (0.424-0.624%) and weber fraction (20.5-33.0%). Meanwhile, sucrose increased citric acid's absolute threshold (0.0057-0.0082%) and decreased its weber fraction (17.96-9.53%). By fitting absolute threshold and weber fraction variation equations, the sweet-sour taste sensory strength variation models (SSTVM) were derived, which could be used to explain the synergy and antagonism effect of sweet-sour taste. According to the SSTVM, the interactive response to sweet-sour taste could be quantitatively calculated. The high coincidence between SSTVM and human evaluation (1.02% of relative error) indicated that it could be applied in the food industry, health management, and intelligent sensory science.
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