Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth

Luguang Zuo; Yuhuan Xu; Shuai Du; Xiaoying Li; Tong Zhao; Yuhong Zhang; Zhenkui Liu; Shutie Li

doi:10.1016/j.cca.2022.07.008

Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth

Clin Chim Acta. 2022 Sep 1:534:77-80. doi: 10.1016/j.cca.2022.07.008. Epub 2022 Jul 16.

Authors

Luguang Zuo¹, Yuhuan Xu², Shuai Du³, Xiaoying Li², Tong Zhao⁴, Yuhong Zhang⁵, Zhenkui Liu⁶, Shutie Li⁷

Affiliations

¹ Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China. Electronic address: zuoluguang@126.com.
² Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
³ Department of Gastroenterology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
⁴ Department of Ultrasound, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
⁵ Department of Obstetrics and Gynecology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
⁶ Department of Pediatrics, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
⁷ Department of Geriatrics, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.

PMID: 35853546
DOI: 10.1016/j.cca.2022.07.008

Abstract

Purpose: Spontaneous preterm birth (SPB) can't be predicted accurately nowadays. We aim to investigate the value of serum amyloid A(SAA) and interleukin-6(IL-6) for forecasting the risk of SPB.

Methods: A total of 302 pregnant women who completed delivery in our hospital from January 2019 to December 2021 were included. According to gestational days, they were divided into the case group (28-33⁺⁶ weeks, 41 cases; 34-36⁺⁶ weeks, 96 cases) and the control group (37-42 weeks, 165 cases). The general data of the two groups were analyzed and the values of SAA and IL-6 in speculating the risk of SPB were studied in this study.

Results: The levels of SAA and IL-6 in the case group were higher than those in the control group(P < 0.05), and the most practical value of SAA and IL-6 access SPB risk were 17.35 mg/L, 112.41 pg/mL respectively. The area under the ROC curve of diagnosis to predict SPB were 0.8849, 0.8664.

Conclusions: The assessment of SPB risk by SAA and IL-6 bearscertain clinical value, which could assist clinicians in recognizing and evaluating the potential dangers of SPB.

Keywords: Diagnostic value; Interleukin-6; Risk prediction; Serum Amyloid A; Spontaneous preterm birth.

MeSH terms

Female
Humans
Infant, Newborn
Interleukin-6
Pregnancy
Premature Birth* / diagnosis
ROC Curve
Serum Amyloid A Protein

Substances

Interleukin-6
Serum Amyloid A Protein