Immunohistochemical expression of CK20, CK7, and CDX2 in colorectal carcinoma in correlation with pathomorphological characteristics

Folia Med (Plovdiv). 2022 Apr 30;64(2):214-220. doi: 10.3897/folmed.64.e60950.

Abstract

Colorectal carcinoma is the third most common cancer worldwide. The usual immunophenotype of colorectal adenocarcinoma is CDX2 positive, CK20 positive, and CK7 negative. Aberrant expression is reported in a variety of colorectal carcinomas but its relation to morphological variables and survival data is still unclear.

Keywords: CRC IHC CK20 CK7 CDX2.

MeSH terms

  • Biomarkers, Tumor* / metabolism
  • CDX2 Transcription Factor
  • Colorectal Neoplasms* / pathology
  • Homeodomain Proteins / metabolism
  • Humans
  • Keratin-20 / metabolism
  • Keratin-7 / metabolism

Substances

  • Biomarkers, Tumor
  • CDX2 Transcription Factor
  • CDX2 protein, human
  • Homeodomain Proteins
  • KRT20 protein, human
  • Keratin-20
  • Keratin-7