The histamine research community has in the last decade been very active and generated a number of exciting new chemical biology tools for the study of histamine receptors, their ligands, and their pharmacology. In this paper we describe the development of histamine receptor structural biology, the use of receptor conformational biosensors, and the development of new ligands for covalent or fluorescent labeling or for photopharmacological approaches (photocaging and photoswitching). These new tools allow new approaches to study histamine receptors and hopefully will lead to better insights in the molecular aspects of histamine receptors and their ligands.
Keywords: Biosensors; Covalent ligands; Fluorescent ligands; Histamine receptor structural biology; Photocaging; Photopharmacology; Photoswitching.
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.