Location, location, location! Rewiring IL-2 circuits defines context-specific outcomes

Lucille Rankin; Daniel Gray

doi:10.1111/imcb.12573

Location, location, location! Rewiring IL-2 circuits defines context-specific outcomes

Immunol Cell Biol. 2022 Sep;100(8):585-587. doi: 10.1111/imcb.12573. Epub 2022 Aug 5.

Authors

Lucille Rankin^{1

2}, Daniel Gray^{1

2}

Affiliations

¹ The Walter and Eliza Hall Institute, Parkville, VIC, Australia.
² Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.

PMID: 35848928
DOI: 10.1111/imcb.12573

Abstract

Here, we highlight a recent publication by Whyte et al. that reveals diverse immune outcomes of interleukin (IL)-2 expression in distinct microenvironments. Their definition of context-dependent IL-2 networks paves the way for the development of tissue-specific therapies that enlist the potent immuno-modulatory activity of IL-2.

Publication types

Comment

MeSH terms

Interleukin-2*

Substances

Interleukin-2