Patulinervones A and B, two novel α-glucosidase inhibitory spiro-lignans from Melicope patulinervia (Merr. & Chun) C.C. Huang

Van-Tuan Vu; Qi-Qi Xu; Huu Tung Nguyen; Ngoc-Hieu Nguyen; Giang-Nam Pham; Ling-Yi Kong; Jian-Guang Luo

doi:10.1080/14786419.2022.2098495

Patulinervones A and B, two novel α-glucosidase inhibitory spiro-lignans from Melicope patulinervia (Merr. & Chun) C.C. Huang

Nat Prod Res. 2023 Oct-Nov;37(21):3639-3646. doi: 10.1080/14786419.2022.2098495. Epub 2022 Jul 18.

Authors

Van-Tuan Vu^{1

2}, Qi-Qi Xu¹, Huu Tung Nguyen², Ngoc-Hieu Nguyen², Giang-Nam Pham³, Ling-Yi Kong¹, Jian-Guang Luo¹

Affiliations

¹ Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, PR China.
² Faculty of Pharmacy, Phenikaa University, Hanoi, Vietnam.
³ Université Côte d'Azur, Nice Institute of Chemistry UMR 7272, Marine Natural Products Team, Nice, France.

PMID: 35848378
DOI: 10.1080/14786419.2022.2098495

Abstract

(±)-Patulinervones A (1) and B (2), two diastereomers of spiro-lignans sharing an unprecedented dimethyl-spiro[furan-2,2'-furo[2,3-b]furan] 5/5/5 tricyclic moiety were isolated from the leaves of Melicope patulinervia (Merr. & Chun) C.C. Huang. Their structures were established by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. The racemates (±)-1 and 2 and their enantiomers exhibited α-glucosidase inhibitory effect with IC₅₀ values range of 10.08 ± 1.24 - 25.58 ± 1.97 µM.

Keywords: Lignans; Melicope patulinervia (Merr. & Chun) C.C. Huang; Rutaceae; α-glucosidase inhibitory effect.