Hsa-let-7d-5p Promotes Gastric Cancer Progression by Targeting PRDM5

Xiang Gao; Huiqi Liu; Rong Wang; Mingyu Huang; Qiong Wu; Yang Wang; Wei Zhang; Yongnian Liu

doi:10.1155/2022/2700651

Hsa-let-7d-5p Promotes Gastric Cancer Progression by Targeting PRDM5

J Oncol. 2022 Jul 7:2022:2700651. doi: 10.1155/2022/2700651. eCollection 2022.

Authors

Xiang Gao^{1

2

3

4

5}, Huiqi Liu^{4

5}, Rong Wang^{4

5}, Mingyu Huang^{4

5}, Qiong Wu^{4

5}, Yang Wang^{4

5}, Wei Zhang^{1

2

3}, Yongnian Liu^{4

5}

Affiliations

¹ Research Centre for High Altitude Medicine, Qinghai University, Xining, Qinghai 810001, China.
² The Key Laboratory of Plateau Medicine Ministry of Education, Xining, Qinghai 810001, China.
³ The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Medical College of Qinghai University, Xining, Qinghai 810001, China.
⁴ Research Center for Qinghai Healthy Development, Medical College, Qinghai University, Xining, Qinghai 810001, China.
⁵ Department of Basic Medical Sciences, Medical College, Qinghai University, Xining, Qinghai 810016, China.

Abstract

Gastric cancer (GC) is a common malignant tumor in the digestive system and a significant health burden worldwide. In this study, we found that hsa-let-7d-5p was upregulated in GC cells, promoted GC cell proliferation, migration, and invasion, and reduced apoptosis. Moreover, we found that the expression of PRDM5 (PR domain protein 5) was downregulated in GC cells and upregulated in GC cells treated with hsa-let-7d-5p inhibitor. Further investigation showed that hsa-let-7d-5p was the target of PRDM5, and the functions of hsa-let-7d-5p on GC progression were rescued by PRDM5 overexpression in GC cells. Collectively, our findings suggested that hsa-let-7d-5p promoted the development of GC by targeting PRDM5, indicating that hsa-let-7d-5p could be a promising therapeutic molecule for the treatment of gastric cancer.