The HBV Specially-Related Long Noncoding RNA HBV-SRL Involved in the Pathogenesis of Hepatocellular Carcinoma

Cunzhen Zhang; Lei Lu; Haibei Xin; Minfeng Zhang; Zhiwen Ding; Qiaomei Li; Kuang Chen; Minggen Hu; Shupeng Liu; Nan Li

doi:10.1155/2022/9034105

The HBV Specially-Related Long Noncoding RNA HBV-SRL Involved in the Pathogenesis of Hepatocellular Carcinoma

J Oncol. 2022 Jul 8:2022:9034105. doi: 10.1155/2022/9034105. eCollection 2022.

Authors

Cunzhen Zhang¹, Lei Lu², Haibei Xin¹, Minfeng Zhang¹, Zhiwen Ding¹, Qiaomei Li¹, Kuang Chen³, Minggen Hu³, Shupeng Liu⁴, Nan Li¹

Affiliations

¹ Department of Hepatic Surgery I (Ward I) Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
² Changhai Hospital, Second Military Medical University, Shanghai, China.
³ Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, Beijing, China.
⁴ Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Abstract

Hepatitis B virus (HBV) is one of the major risk factors for HCC (hepatocellular carcinoma) occurrence with a diverse role in the pathogenesis of HCC. More works need to be performed to elucidate a more thorough understanding of the molecular mechanisms involving in HBV-induced HCC, although some mechanisms such as genome integration have been reported. In the present study, aberrantly expressed lncRNAs were identified between HCC tumor tissues with or without HBV infection. Among these molecules, HBV specially-related long noncoding RNA (HBV-SRL) was further found to correlate with poor prognosis and a shorter overall survival time in HCC patients with HBV infection. Additionally, HBV-SRL was found function as oncogene by upregulating the NF-κB2 expression. These data suggest that HBV infection altered gene expression pattern in liver cells which contributed to HBV-related HCC development, and HBV-SRL may serve as a new molecular marker or potential therapeutic target of HBV-related HCC.