Comparison of Sensory Observation and Somatosensory Stimulation in Mirror Neurons and the Sensorimotor Network: A Task-Based fMRI Study

Zhiqing Zhou; Songmei Chen; Yuanli Li; Jingjun Zhao; Guanwu Li; Lei Chen; Yuwei Wu; Sicong Zhang; Xiaolong Shi; Xixi Chen; Shutian Xu; Meng Ren; Shixin Chang; Chunlei Shan

doi:10.3389/fneur.2022.916990

Comparison of Sensory Observation and Somatosensory Stimulation in Mirror Neurons and the Sensorimotor Network: A Task-Based fMRI Study

Front Neurol. 2022 Jun 30:13:916990. doi: 10.3389/fneur.2022.916990. eCollection 2022.

Authors

Zhiqing Zhou^{1

2}, Songmei Chen^{2

3}, Yuanli Li⁴, Jingjun Zhao^{1

2}, Guanwu Li⁵, Lei Chen⁵, Yuwei Wu^{1

2}, Sicong Zhang^{1

2}, Xiaolong Shi^{1

2}, Xixi Chen^{1

2}, Shutian Xu⁴, Meng Ren^{1

2}, Shixin Chang⁵, Chunlei Shan^{1

2

4}

Affiliations

¹ Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
³ Department of Rehabilitation Medicine, Shanghai No. 3 Rehabilitation Hospital, Shanghai, China.
⁴ Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China.
⁵ Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Objective: This study aimed to investigate brain plasticity by somatosensory stimulation (SS) and sensory observation (SO) based on mirror neuron and embodied cognition theory. Action observation therapy has been widely adopted for motor function improvement in post-stroke patients. However, it is uncertain whether the SO approach can also contribute to the recovery of sensorimotor function after stroke. In this study, we explored the therapeutic potential of SO for sensorimotor dysfunction and provided new evidence for neurorehabilitation.

Methods: Twenty-six healthy right-handed adults (12 men and 14 women), aged 18-27 (mean, 22.12; SD, 2.12) years were included. All subjects were evaluated with task-based functional magnetic resonance imaging (fMRI) to discover the characteristics and differences in brain activation between SO and SS. We adopted a block design with two conditions during fMRI scanning: observing a sensory video of brushing (task condition A, defined as SO) and brushing subjects' right forearms while they watched a nonsense string (task condition B, defined as SS). One-sample t-tests were performed to identify brain regions and voxels activated for each task condition. A paired-sample t-test and conjunction analysis were performed to explore the differences and similarities between SO and SS.

Results: The task-based fMRI showed that the bilateral postcentral gyrus, left precentral gyrus, bilateral middle temporal gyrus, right supramarginal gyrus, and left supplementary motor area were significantly activated during SO or SS. In addition to these brain regions, SO could also activate areas containing mirror neurons, like the left inferior parietal gyrus.

Conclusion: SO could activate mirror neurons and sensorimotor network-related brain regions in healthy subjects like SS. Therefore, SO may be a promising novel therapeutic approach for sensorimotor dysfunction recovery in post-stroke patients.

Keywords: functional magnetic resonance imaging; mirror neurons; sensorimotor network; sensory observation; somatosensory stimulation.