Immediate postnatal central hypothyroidism caused by maternal Graves' disease: Importance of early screening

Saho Tochibora; Tomohiro Hori; Mai Mori; Hideki Matsumoto; Hiroki Otsuka; Hideo Sasai; Yuko Ito; Yukiko Kasahara; Norio Kawamoto; Hidenori Ohnishi

doi:10.1002/ccr3.6061

Immediate postnatal central hypothyroidism caused by maternal Graves' disease: Importance of early screening

Clin Case Rep. 2022 Jul 14;10(7):e6061. doi: 10.1002/ccr3.6061. eCollection 2022 Jul.

Authors

Saho Tochibora^{1

2}, Tomohiro Hori^{1

2

3}, Mai Mori^{1

2}, Hideki Matsumoto^{1

2}, Hiroki Otsuka^{1

2

3}, Hideo Sasai^{1

2

3}, Yuko Ito^{1

2}, Yukiko Kasahara^{1

2

4}, Norio Kawamoto^{1

2}, Hidenori Ohnishi^{1

2

3}

Affiliations

¹ Department of Pediatrics, Graduate School of Medicine Gifu University Gifu Japan.
² Division of Neonatal Intensive Care Unit Gifu University Hospital Gifu Japan.
³ Clinical Genetics Center Gifu University Hospital Gifu Japan.
⁴ Department of Pediatrics Matsunami General Hospital Gifu Japan.

Abstract

This report illustrates a case of central hypothyroidism in a newborn immediately after birth caused by maternal Graves' disease. Infants from mothers with Graves' disease require careful examination without waiting for neonatal screening results, even though the mother's thyroid function is normal at birth or the newborn does not have goiter.

Keywords: Wolff–Chaikoff effect; central hypothyroidism; congenital hypothyroidism; maternal Graves' disease.

Publication types

Case Reports