Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10)

Tomohiro Horio; Megumi Enomoto; Masaya Watarai; Yuuta Nakano; Saki Yamada; Saori Matsumura; Jo Kanasugi; Soichi Takasugi; Ayano Nakamura; Kaori Uchino; Shohei Mizuno; Satsuki Murakami; Hidesuke Yamamoto; Ichiro Hanamura; Akiyoshi Takami

doi:10.1002/jha2.115

Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10)

EJHaem. 2020 Oct 8;1(2):558-562. doi: 10.1002/jha2.115. eCollection 2020 Nov.

Authors

Tomohiro Horio^{1

2}, Megumi Enomoto³, Masaya Watarai⁴, Yuuta Nakano^{1

2}, Saki Yamada⁴, Saori Matsumura^{1

2}, Jo Kanasugi^{1

2}, Soichi Takasugi^{1

2}, Ayano Nakamura^{1

2}, Kaori Uchino^{1

2}, Shohei Mizuno^{1

2}, Satsuki Murakami^{1

2}, Hidesuke Yamamoto^{1

2}, Ichiro Hanamura^{1

2}, Akiyoshi Takami^{1

2}

Affiliations

¹ Division of Hematology Department of Internal Medicine School of Medicine Aichi Medical University Nagakute Japan.
² Hematopoietic Cell Transplantation Center Aichi Medical University Hospital Nagakute Japan.
³ Department of Clinical Laboratory Aichi Medical University Hospital Nagakute Japan.
⁴ Department of Hematology and Chemotherapy Daido Hospital Nagoya Japan.

Abstract

Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3-year survival rate of 86%; in contrast, the remaining six cases had a 3-year survival rate of 0% (P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis.

Keywords: DNA mutation; MDS; cytogenetics.