Imaging of Normal Brain Aging

Yoshiaki Ota; Gaurang Shah

doi:10.1016/j.nic.2022.04.010

Imaging of Normal Brain Aging

Neuroimaging Clin N Am. 2022 Aug;32(3):683-698. doi: 10.1016/j.nic.2022.04.010.

Authors

Yoshiaki Ota¹, Gaurang Shah²

Affiliations

¹ Division of Neuroradiology, Department of Radiology, University of Michigan, 1500 East Medical Center Drive, UH B2, Ann Arbor, MI 48109, USA.
² Division of Neuroradiology, Department of Radiology, University of Michigan, 1500 East Medical Center Drive, UH B2, Ann Arbor, MI 48109, USA. Electronic address: gvshah@med.umich.edu.

PMID: 35843669
DOI: 10.1016/j.nic.2022.04.010

Abstract

Understanding normal brain aging physiology is essential to improving healthy human longevity, differentiation, and early detection of diseases, such as neurodegenerative diseases, which are an enormous social and economic burden. Functional decline, such as reduced physical activity and cognitive abilities, is typically associated with brain aging. The authors summarize the aging brain mechanism and effects of aging on the brain observed by brain structural MR imaging and advanced neuroimaging techniques, such as diffusion tensor imaging and functional MR imaging.

Keywords: Aging mechanism; CAA; DTI; Lacunes; Microbleed; Structural MRI; WMH; fMRI.

Publication types

Review

MeSH terms

Aging / physiology
Brain*
Diffusion Tensor Imaging* / methods
Humans
Magnetic Resonance Imaging
Neuroimaging / methods