Extracellular vesicles for improved tumor accumulation and penetration

Nana Bie; Tuying Yong; Zhaohan Wei; Lu Gan; Xiangliang Yang

doi:10.1016/j.addr.2022.114450

Extracellular vesicles for improved tumor accumulation and penetration

Adv Drug Deliv Rev. 2022 Sep:188:114450. doi: 10.1016/j.addr.2022.114450. Epub 2022 Jul 14.

Authors

Nana Bie¹, Tuying Yong¹, Zhaohan Wei¹, Lu Gan², Xiangliang Yang³

Affiliations

¹ National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
² National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China; Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: lugan@hust.edu.cn.
³ National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China; Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: yangxl@hust.edu.cn.

PMID: 35841955
DOI: 10.1016/j.addr.2022.114450

Abstract

Extracellular vesicles (EVs), including microparticles and exosomes, have emerged as potential tools for tumor targeting delivery during the past years. Recently, mass of strategies are applied to assist EVs to accumulate and penetrate into deep tumor sites. In this review, EVs from different cells with unique innate characters and engineered approaches (e.g. chemical engineering, genetical engineering and biomimetic engineering) as drug delivery systems to enhance tumor accumulation and penetration are summarized. Meanwhile, efficient biological function modulation (e.g. extracellular matrix degradation, mechanical property regulation and transcytosis) is introduced to facilitate tumor accumulation and penetration of EVs. Finally, the prospects and challenges on further clinical applications of EVs are discussed.

Keywords: Drug delivery; Extracellular matrix regulation; Extracellular vesicles; Mechanical deformability; Transcytosis; Tumor accumulation and penetration; Tumor-homing targeting.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems
Exosomes* / metabolism
Extracellular Vesicles* / metabolism
Humans
Neoplasms* / drug therapy
Neoplasms* / metabolism
Transcytosis