Nanostructured Cu-doped TiO2 with photothermal effect for prevention of implant-associated infection

Shuxin Lu; Ruoyu Li; Maozhou Chai; Jiameng Wang; Wangping Duan; Xiaohong Yao; Xiangyu Zhang; Bin Tang

doi:10.1016/j.colsurfb.2022.112695

Nanostructured Cu-doped TiO₂ with photothermal effect for prevention of implant-associated infection

Colloids Surf B Biointerfaces. 2022 Sep:217:112695. doi: 10.1016/j.colsurfb.2022.112695. Epub 2022 Jul 9.

Authors

Shuxin Lu¹, Ruoyu Li², Maozhou Chai³, Jiameng Wang², Wangping Duan⁴, Xiaohong Yao², Xiangyu Zhang⁵, Bin Tang⁶

Affiliations

¹ Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Institute of Energy Innovation, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
² Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
³ College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
⁴ Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
⁵ Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China. Electronic address: zhangxiangyu@tyut.edu.cn.
⁶ Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China. Electronic address: tangbin@tyut.edu.cn.

PMID: 35841800
DOI: 10.1016/j.colsurfb.2022.112695

Abstract

Bacterial infection of titanium (Ti) dental implants is still a major clinical complication. In this study, a combination of copper (Cu) ions and photothermal therapy is used to combat implant-associated infection. Cu doped TiO₂ (TiO₂-Cu) films were prepared on Ti by magnetron sputtering and subsequently annealing. TiO₂-Cu films had efficient photothermal conversion ability due to the generated nanostructure during the annealing process. Under the irradiation of 808 near infrared light, the combined actions of hyperthermia and Cu ions gave rise to excellent antibacterial activity against Streptococcus mutans on Ti as demonstrated by the experiments conducted in vitro and in vivo. The TiO₂-Cu films also exhibited excellent biocompatibility. In addition, the surface hardness and corrosion resistance of TiO₂-Cu films were greatly improved.

Keywords: Antibacterial property; Photothermal therapy; TiO(2)-Cu film; Titanium.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Copper / chemistry
Copper / pharmacology
Corrosion
Nanostructures*
Titanium* / chemistry
Titanium* / pharmacology

Substances

Anti-Bacterial Agents
titanium dioxide
Copper
Titanium