A review of radical and non-radical degradation of amoxicillin by using different oxidation process systems

Abstract

Pharmaceutical compounds have piqued the interest of researchers due to an increase in their demand, which increases the possibility of leakage into the environment. Amoxicillin (AMX) is a penicillin derivative used for the treatment of infections caused by gram-positive bacteria. AMX has a low metabolic rate in the human body, and around 80-90% is unmetabolized. As a result, AMX residuals should be treated immediately to avoid further accumulation in the environment. Advanced oxidation process techniques are an efficient way to degrade AMX. This review attempts to collect, organize, summarize, and analyze the most up to date research linked to the degradation of AMX by different advanced oxidation process systems including photocatalytic, ultrasonic, electro-oxidation, and advanced oxidation process-based on partials. The main topics investigated in this review are degradation mechanism, degradation efficiency, catalyst stability, the formation of AMX by-products and its toxicity, in addition, the influence of different experimental conditions was discussed such as pH, temperature, scavengers, the concentration of amoxicillin, oxidants, catalyst, and doping ratio. The degradation of AMX could be inhibited by very high values of pH, temperature, AMX concentration, oxidants concentration, catalyst concentration, and doping ratio. Several AMX by-products were discovered after oxidation treatment, and several of them had lower or same values of LC₅₀ (96 h) fathead minnow of AMX itself, such as m/z 384, 375, 349, 323, 324, 321, 318, with prediction values of 0.70, 1.10, 1.10 0.42, 0.42, 0.42, and 0.42 mg/L, respectively. We revealed that there is no silver bullet system to oxidize AMX from an aqueous medium. However, it is recommended to apply hybrid systems such as Photo-electro, Photo-Fenton, Electro-Fenton, etc. Hybrid systems are capable to cover the drawbacks of the single system. This review may provide important information, as well as future recommendations, for future researchers interested in treating AMX using various AOP systems, allowing them to improve the applicability of their systems and successfully oxidize AMX from an aqueous medium.

Keywords: Advanced oxidation process; Amoxicillin; By-products; Catalyst stability; Mechanism; Toxicity.