Synthesis of magnetic/pH dual responsive dextran hydrogels as stimuli-sensitive drug carriers

Abstract

Hydrogels loaded with magnetic nanoparticles have been widely researched recently as biomaterials, due to their good biocompatibility and unique magnetic characteristics. In this study, water-soluble superparamagnetic iron oxide nanoparticles (Fe₃O₄) prepared by coprecipitation were physically doped into the dextran hydrogels which were formed via Schiff base reactions between ethylenediamine and oxidized dextran. The combination of magnetic nanoparticles and chemical cross-linked hydrogels leads to magnetic/pH dual-sensitive hydrogels which can be used as stimuli-responsive carrier. Magnetic properties, swelling, and rheology behaviors of the resulted magnetic hydrogels were strongly affected by the Fe₃O₄ nanoparticle content. Moreover, doxorubicin (DOX⋅HCl) was embedded into the magnetic hydrogels and pH/magnetic sensitive release profiles were identified. The release mechanism analysis indicated that the release behaviors of DOX⋅HCl were controlled by the diffusion, swelling, and erosion processes simultaneously. The prepared hydrogel/Fe₃O₄ composites with dual magnetic/pH stimuli-responsiveness hold the promise to be used in various applications such as drug release.

Keywords: Dextran; Doxorubicin; Drug carrier; Magnetic iron oxide; Stimuli-sensitive hydrogel.