The mammalian reproduction is a process of controlled cellular growth and development regulated by constant communication between the gametes, the subsequent embryo and the maternal system. Extracellular vesicles (EVs) are involved in these communications to a significant degree from the gamete production and maturation to fertilization, embryo development and implantation. They regulate the cellular physiology and the immune reaction to bring about a favourable environment for a successful pregnancy. Deciphering the mechanisms employed in EV-mediated embryo maternal communication could improve our knowledge in mammalian reproduction and increase the efficiency of animal breeding.
Keywords: embryo-maternal communication; extracellular vesicles; immune regulation; intercellular signalling; maternal recognition of pregnancy.
© 2022 The Authors. Reproduction in Domestic Animals published by Wiley-VCH GmbH.