Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF

Jingjing Tong; Mingjie Yao; Xiuying Mu; Leijie Wang; Xiajie Wen; Xingran Zhai; Xiang Xu; Yu Wang; Jing Chen; Xiangwei Zhai; Chongdan Guan; Fengmin Lu; Jinhua Hu

doi:10.14218/JCTH.2020.00133

Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF

J Clin Transl Hepatol. 2022 Jun 28;10(3):449-457. doi: 10.14218/JCTH.2020.00133. Epub 2022 Jan 4.

Authors

Jingjing Tong^{1

2}, Mingjie Yao³, Xiuying Mu⁴, Leijie Wang⁵, Xiajie Wen⁵, Xingran Zhai⁴, Xiang Xu², Yu Wang¹, Jing Chen^{1

2}, Xiangwei Zhai⁵, Chongdan Guan², Fengmin Lu⁵, Jinhua Hu^{1

2

4}

Affiliations

¹ Chinese PLA Medical School, Beijing, China.
² Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing, China.
³ Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
⁴ Peking University 302 Clinical Medical School, Beijing, China.
⁵ Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Abstract

Background and aims: As a hepatocellular carcinoma biomarker, serum Golgi protein 73 (GP73) is reportedly related to inflammation. Acute-on-chronic liver failure (ACLF) is characterized by severe systemic inflammation. In this study, we aimed to explore the association between the GP73 level and short-term mortality in patients with alcohol-associated liver disease-related ACLF (ALD-ACLF).

Methods: This retrospective cohort study involved 126 Chinese adults with ALD-ACLF. Baseline serum GP73 level was measured using enzyme-linked immunosorbent assay. Patients were followed-up for 90 d and outcomes were assessed. Data were analyzed using multivariate Cox regression and piecewise linear regression analyses. The predictive value of GP73 and classic models for the short-term prognosis of participants were evaluated and compared using receiver operating characteristic curves.

Results: The serum GP73 level was independently associated with an increased mortality risk in patients with ALD-ACLF. Compared with the lowest tertile, the highest serum GP73 level predisposed patients with ALD-ACLF to a higher mortality risk in the fully adjusted model [at 28 days: hazard ratio (HR): 4.29 (0.99-18.54), p=0.0511; at 90 days: HR: 3.52 (1.15-10.79), p=0.0276]. Further analysis revealed a positive linear association. GP73 significantly improved the accuracy of the Child-Turcotte-Pugh score, model for end-stage liver disease score, and model for end-stage liver disease-sodium score in predicting short-time prognosis of patients with ALD-ACLF.

Conclusions: The serum GP73 level is a significant predictor of the subsequent risk of death in patients with ALD-ACLF. GP73 improved the predictive value of classic prognostic scores.

Keywords: Acute-on-chronic liver failure (ACLF); Alcohol-associated liver disease; Golgi protein 73 (GP73); Prognosis; Retrospective cohort study.