m6A-modified circRNAs: detections, mechanisms, and prospects in cancers

Shiyi Qin; Qi Zhang; Yanhua Xu; Shuo Ma; Tianyi Wang; Yuejiao Huang; Shaoqing Ju

doi:10.1186/s10020-022-00505-5

m⁶A-modified circRNAs: detections, mechanisms, and prospects in cancers

Mol Med. 2022 Jul 14;28(1):79. doi: 10.1186/s10020-022-00505-5.

Authors

Shiyi Qin^#^{1

2

3}, Qi Zhang^#^{1

2

3}, Yanhua Xu^{1

2

3}, Shuo Ma^{1

2

3}, Tianyi Wang^{1

2

3}, Yuejiao Huang^{4

5

6}, Shaoqing Ju⁷

Affiliations

¹ Medical School of Nantong University, Nantong University, No. 19, Qixiu Road, Nantong, 226001, Jiangsu, China.
² Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Nantong, 226001, Jiangsu, China.
³ Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
⁴ Medical School of Nantong University, Nantong University, No. 19, Qixiu Road, Nantong, 226001, Jiangsu, China. huangyuejiao20@126.com.
⁵ Department of Medical Oncology, Affiliated Tumor Hospital of Nantong University, Nantong, 226001, Jiangsu, China. huangyuejiao20@126.com.
⁶ Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China. huangyuejiao20@126.com.
⁷ Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Nantong, 226001, Jiangsu, China. jsq814@hotmail.com.

^# Contributed equally.

Abstract

Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N⁶-methyladenosine (m⁶A), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processes of various diseases. An increasing amount of evidence has suggested that m⁶A modification is common in circRNAs and is associated with their biological functions. This review summarizes the effects of m⁶A modification on circRNAs and their regulation mechanisms in cancers, providing some suggestions of m⁶A-modified circRNAs in cancer therapy.

Keywords: Cancers; CircRNA; Metabolism; N6-methyladenosine; Non-coding RNAs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Neoplasms* / genetics
RNA, Circular* / genetics

Substances

RNA, Circular