Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis

Cell Mol Life Sci. 2022 Jul 14;79(8):422. doi: 10.1007/s00018-022-04447-3.

Abstract

Microtubule dynamics ensure multiple cellular events during oocyte meiosis, which is critical for the fertilization and early embryo development. KIF15 (also termed Hklp2) is a member of kinesin-12 family motor proteins, which participates in Eg5-related bipolar spindle formation in mitosis. In present study, we explored the roles of KIF15 in mouse oocyte meiosis. KIF15 expressed during oocyte maturation and localized with microtubules. Depletion or inhibition of KIF15 disturbed meiotic cell cycle progression, and the oocytes which extruded the first polar body showed a high aneuploidy rate. Further analysis showed that disruption of KIF15 did not affect spindle morphology but resulted in chromosome misalignment. This might be due to the reduced stability of the K-fibers, which further induced the loss of kinetochore-microtubule attachment and activated spindle assembly checkpoint, showing with the failed release of Bub3 and BubR1. Based on mass spectroscopy analysis and coimmunoprecipitation data we showed that KIF15 was responsible for recruiting HDAC6, NAT10 and SIRT2 to maintain the acetylated tubulin level, which further affected tubulin acetylation for microtubule stability. Taken together, these results suggested that KIF15 was essential for the microtubule acetylation and cell cycle control during mouse oocyte meiosis.

Keywords: Aneuploidy; Cell cycle; Meiosis; Microtubule; Oocyte.

MeSH terms

  • Acetylation
  • Animals
  • Kinesins* / genetics
  • M Phase Cell Cycle Checkpoints
  • Meiosis
  • Mice
  • Microtubules / metabolism
  • Oocytes / metabolism
  • Spindle Apparatus / metabolism
  • Tubulin* / metabolism

Substances

  • Tubulin
  • Kinesins