The dominoes fall after long-term antibiotic exposure

Bing Zhai; Robert T Wheeler

doi:10.1016/j.chom.2022.06.007

The dominoes fall after long-term antibiotic exposure

Cell Host Microbe. 2022 Jul 13;30(7):903-905. doi: 10.1016/j.chom.2022.06.007.

Authors

Bing Zhai¹, Robert T Wheeler²

Affiliations

¹ CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address: bing.zhai@siat.ac.cn.
² Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Sciences, University of Maine, Orono, ME, USA. Electronic address: robert.wheeler1@maine.edu.

Abstract

Broad-spectrum antibiotics should prevent disease, right? In this issue of Cell Host & Microbe, Drummond et al. turn logic on its head and show they actually drive more deadly invasive fungal-bacterial systemic co-infection. Prophylactic antibiotics increase susceptibility to these infections by targeting the commensal microbes required for gut-derived IL-17-mediated immunity.

Publication types

Comment

MeSH terms

Anti-Bacterial Agents* / pharmacology
Anti-Bacterial Agents* / therapeutic use
Bacteria*
Symbiosis

Substances

Anti-Bacterial Agents

Grants and funding

R15 AI133415/AI/NIAID NIH HHS/United States